American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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What is the second least potent steroid according to the potency classification?

  1. Dexamethasone

  2. Hydrocortisone

  3. Prednisone

  4. Methylprednisone

The correct answer is: Prednisone

In the context of corticosteroid potency, prednisone is classified as a mid-potency steroid. It is less potent than dexamethasone, which is a high-potency corticosteroid, and methylprednisolone, which also has a comparatively higher potency than prednisone. Hydrocortisone is typically regarded as the least potent corticosteroid, frequently used in situations requiring less powerful anti-inflammatory effects. Prednisone, therefore, falls as the second least potent when compared to hydrocortisone and others in the list, while still providing substantial therapeutic effects in a variety of conditions, especially in the management of autoimmune disorders and inflammatory conditions. Understanding the relative potencies of these steroids is crucial for appropriate prescribing practices and for preventing potential side effects associated with higher potency steroids.

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