American Board of Surgery Qualifying Exam (ABS QE) Practice Test

Disable ads (and more) with a membership for a one time $2.99 payment

Prepare for the American Board of Surgery Qualifying Exam with our interactive quizzes. Utilize detailed flashcards and multiple-choice questions to enhance your learning. Each question is complemented with hints and explanations to help you ace the exam!

Start Multiple Choice Practice Test
Start Flash Cards

Each practice test/flash card set has 50 randomly selected questions from a bank of over 500. You'll get a new set of questions each time!

Practice this question and more.

What is the mechanism of action of Sirolimus?

  1. Inhibits calcineurin

  2. Inhibits mTOR and decreases IL-2

  3. Blocks histamine receptors

  4. Depletes T-cell populations

The correct answer is: Inhibits mTOR and decreases IL-2

Sirolimus, also known as rapamycin, primarily functions as an immunosuppressant by inhibiting the mammalian target of rapamycin (mTOR), which is a crucial regulatory protein involved in cell growth, proliferation, and survival. By blocking mTOR, sirolimus effectively reduces the production of cytokines such as interleukin-2 (IL-2), which is essential for T-cell activation and proliferation. This suppression leads to a decrease in T-cell response, making sirolimus particularly useful in preventing organ transplant rejection and in treating certain malignancies. In understanding this mechanism, it's important to recognize that inhibiting mTOR plays a significant role in modulating the immune response, thereby providing its therapeutic effects. The reduction of IL-2 is a direct consequence of mTOR inhibition, highlighting how sirolimus specifically targets pathways involved in T-cell activation and lymphocyte proliferation.

More Questions Like This